Kollicoat IR®, a new pharmaceutical excipient developed as a coating polymer for instant release tablets, was evaluated as a carrier in solid dispersions of. Kollicoat® IR, a graft copolymer comprised of polyethylene glycol and polyvinyl alcohol (PEG: PVA, ), has been used as an instant release. Cech T., Kolter K. , Influence of plasticizer on the film properties of HPMC and PVA and comparison of the results with the properties of Kollicoat® IR as.
|Published (Last):||18 February 2010|
|PDF File Size:||7.56 Mb|
|ePub File Size:||14.96 Mb|
|Price:||Free* [*Free Regsitration Required]|
Please provide a valid registered E-Mail ID. Thus, PEG-PVA with remarkable properties as binder and coating polymer, and free of peroxides, brings a new generation of excipient that could be widely applied to a range of wet granulation formulation development of highly sensitive drugs prone to oxidative degradation. Highly flexible film thanks to integrated plasticizer.
Kollicoat® IR: Minimizing the Risks for Oxidative Degradation of Drugs
Poster Using different coating technologies to apply a functional film-coating polymer onto drug layered pellets Download. The stability of active ingredients depends on external factors, e. No part of this content may be reproduced or transmitted in any form or by any means as per the standard guidelines of fair use.
You will find the unsubscribe link at the end of each newsletter you receive.
There was a problem providing the content you requested
Portfolio Overview Focusing on your needs with platform solutions Read. For instance, wet granulation though remains widely practiced in the industry for its simplicity and easy scale up, can exert an enormous mechanical stress on the excipients caused by multiple formulation steps involving blending, mixing, granulation, drying, and sieving .
Wet binder in formulation of ascorbic acid tablet The properties of PEG-PVA as a binder have been evaluated in wet and fluid bed granulations . The stability data, as shown in Table 5, suggests that raloxifene tablets with PEG-PVA were stable over 6 month period without degradation. Please choose your subindustry. MedCrave Group is ardent to provide article reprints at an instant affordable Read more J Anal Pharm Res 2 3: Minimizing the Risks for Oxidative Degradation of Drugs.
Those residual peroxides typically originate during the manufacturing process and get carried over practically in many of the excipients used in formulation. In a subsequent investigation, Yarkala et al. Raloxifene, bearing a tertiary amine and being highly sensitive to oxidation, has been investigated to demonstrate the feasibility of PEG-PVA as an alternative binder to control oxidative degradation to N-oxide, and perhaps other sensitive drugs alike.
Based on a work at https: Please check your mailbox for further information. The data also demonstrate that the fluid bed granules were highly compressible as compared to those prepared by high shear granulation due to high porosity. Due to its low viscosity values in aqueous solutions, easy processing in a vast process parameter range is assured. Thus, controlling these impurities is important in alleviating the degradants to enhance the shelf life of drug products.
As wet binderit combines powerful binding with no peroxides at all.
Cookies kolliicoat us deliver our services. This study is aimed at examining the impact of peroxides on degradation of drug in formulations prepared by wet granulation and finds the appropriate excipients to mitigate the risks for degradation. Country Please choose your country. Click here to submit your manuscript Peroxides, amongst many of the impurities, remain the most challenging in drug development.
As wet binderit provides high binding efficiency. With increasing amounts of peroxides spiked with hydrogen peroxide the formation of N-oxide increased causing a significant loss inpotency of drug . And all those characteristics also make it a great pore former for sustained release formulations.
Controlling the residual peroxides is therefore critical to improve long term stability and to maintain the quality of pharmaceutical dosage forms, and the research continues to find the kpllicoat solutions. In the high shear mixing, the granules however were densely packed, less ig, and kollkcoat were less compressible. Unless noted otherwise, the statistical analysis was not performed as all the data points were a single measurement on each individual samples.
The stability data reveal that the peroxide level does not increase at ambient and accelerated stability conditions.
Stability condition 3 mo. Download Center Looking for application guides, technical and scientific posters, brochures or technical Information? Poster Evaluating various wet binders to gain lactose based agglomerates applicable for ODT Download. Please retry again later.
HelloYou are logged in with access to additional information.
Therefore, the efforts continue to identify the appropriate excipients lacking peroxides, or having significantly low peroxides to alleviate the oxidative degradation. April 22, Published: Highly reliable, cost-effective processes that produce first-class results every time.
Link to reset your password has been sent to your provided E-Mail ID. PEG-PVA, developed first as an instant release coating polymer for immediate release coatings, has also been used as a hydrophilic pore former in the drug layering for sustained release tablets . Keep me logged in. Granule properties such oollicoat particle size and compression profile were evaluated, and compared with copovidone and HMPC granules. Likewise, the tablets with povidone Kolliocat bearing the low peroxide e.
Compression profiles of ascorbic acid tablets prepared from the granules prepared by fluid bed and high shear granulations; the compressions were carried out on each individual samples, hence no statistical data. These impurities may lead to undesired reactions and alter the efficacy of dosages with possibly adverse effects . The hardness of the granules, increased as a function of compression forces in both fluid bed and high shear granulations.
Back to registration form. Please provide your registered UserId to reset your password.