Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. Eur J Haematol Suppl. Mar;(71) doi: /j x. Immune thrombocytopenic purpura: epidemiology and implications for.

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An analysis for anti-platelet antibodies is a matter of clinician’s preference, as there is disagreement on whether the 80 percent specificity of this test is sufficient to be clinically useful.

Freckles lentigo melasma nevus melanoma. Bleeding time is usually prolonged in ITP patients. All the petechial lesions were completely resolved over the idjopatik, arm, and forearms.


Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines [10] and a normal bleeding time does not exclude a platelet disorder. However, while sometimes effective, it is costly and produces improvement that generally lasts less than a month.

In fact, an enlarged trombositopenai should lead to a search for other possible causes for the thrombocytopenia.

Hematol Oncol Clin North Am. After several weeks of prednisone therapy, the dose is gradually reduced.

Immune thrombocytopenic purpura: epidemiology and implications for patients.

Platelet transfusions may be performed in newborns, depending on the degree of thrombocytopenia. Based on the rrombositopenia findings, provisional diagnosis was made as ITP.

The gastric pathogen Helicobacter pylori H. Hence one may be considered thrombocytopenic below that range, although the threshold for a diagnosis of ITP is not tied to any specific number. Acknowledgements The authors declare no conflict of interest or commercial affiliation related to this study.


This tromboeitopenia because the underlying autoimmune mechanism that destroyed the patient’s platelets to begin with will also destroy donor platelets. Petechia, purpura, and easy bruising are expected in ITP. An upper gastrointestinal endoscopy showed fundal and corpus hemorrhagic gastritis and biopsy test for the presence of H. The exact mechanism by which dapsone assists in ITP is unclear. The spleen is the site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp.

However, consistent with the findings of Michel et al [ 9 ], others have reported neither an increased incidence of H.

ITP is diagnosed by a low platelet count in a complete blood count a common blood test. The bleeding manifestations of thrombocytopenia are described as mucocutaneous to distinguish them from coagulation disorders like hemophilia. Adults are usually pupura on a steroid medicine called prednisone. Transfusion-associated graft versus host disease. Initial treatment usually consists of the administration of corticosteroidsa group of medications that suppress the immune system.

This website also contains material copyrighted by 3rd parties. The procedure is potentially risky in ITP cases due to the increased possibility of significant bleeding during surgery. Diagnosis and treatment of purpuura thrombocytopenic purpura: Abstract Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. However, while sometimes effective, it is costly and produces improvement that generally lasts less than a month.

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N Engl J Med ; Chronic idiopathic thrombocytopenic purpura. Other immunosuppresants, which are steroid sparing drugs like mycophenolate mofetil and azathioprine, are becoming more popular for their effectiveness.

In approximately 60 percent of cases, antibodies against platelets can be detected.

It is more common in children than adults. A bone purpkra aspiration or biopsy may also be done. As most causes appear to be related to antibodies against platelets, it is also known as immune thrombocytopenic purpura.


The major causes of accelerated platelet consumption include immune thrombocytopenia, decreased bone marrow production, and increased splenic sequestration. Intraorally there was complete resolution of hematoma anteriorly on gingiva [ Figure 6 ], hematoma in lower anterior lingual region [ Figure 7 ], and petechiae over dorsum of tongue.

Archived from the original on Please review our privacy policy. Care, Recommendations, and Protecting Practitioners. The mortality rate due to chronic ITP varies but tends to be higher relative to the general population for any age range. In acute ITP, the stimulus for autoantibody production is also unknown; platelet membrane cryptantigens may become exposed by the stress of infection, or pseudoantigens may be formed by the passive adsorption of pathogens on platelet surfaces.

Pertinent investigations were advised to the patient. Petechial spots on dorsum of tongue, petechial spot on left side hard palate and left maxillary tuberosity region. The epidemiology of immune thrombocytopenic purpura.


In chronic refractory cases, where immune pathogenesis has been confirmed, [15] the off-label use of the vinca alkaloid [16] [17] [18] and trombositopeni agent vincristine may be attempted.

From Wikipedia, the free encyclopedia. Graves’ disease Myasthenia gravis Pernicious anemia. ABC of clinical haematology. Intravenous immunoglobulin IVIg may be infused in some cases in order to decrease the rate at which macrophages consume antibody -tagged platelets. It should be limited idioaptik duration unless demonstrated that symptomatic thrombocytopenia persists.

Management of immune thrombocytopenic purpura in pregnancy.