ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

Author: Meztilkis Faukasa
Country: Belarus
Language: English (Spanish)
Genre: Education
Published (Last): 9 October 2011
Pages: 14
PDF File Size: 1.56 Mb
ePub File Size: 2.81 Mb
ISBN: 817-2-78649-840-5
Downloads: 98641
Price: Free* [*Free Regsitration Required]
Uploader: Dougrel

Ertapenem for Injection

Carbapenem hypersensitivity, cephalosporin hypersensitivity, penicillin hypersensitivity. By day 5 after discontinuation, the concentration in breast milk was undetectable.

Minor Probenecid inhibits the renal excretion of ertapenem by competing with them for active tubular secretion. If possible, avoid coadministration. If ertapenemm drugs are coadministered and serum valproic acid concentrations cannot be maintained or if seizures occur, alternative antibacterial or anticonvulsant therapy should be considered. IM use is contraindicated in patients with an amide local anesthetic hypersensitivity. Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.

Do not co-infuse with other medications. It inhibits the third and final stage of ertapeenem cell wall synthesis by preferentially binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall. Case studies have reported ertapenem causing decreases in valproic acid and divalproex serum concentrations when ertapenem was added to their regimen; discontinuation of ertapenem resulted in increased valproic acid concentrations.

The exact mechanism of this interaction is not known, however, based on in vitro and animal data, inhibition of valproic acid glucuronide hydrolysis is a suggested mechanism.

Data regarding inserg contraceptives or for newer combined contraceptive deliveries e. Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, pacjage, and penicillin derivatives. Lidocaine is the diluent for IM administration of ertapenem.

  AMIBIASIS EN LACTANTES PDF

If an allergic reaction occurs, discontinue the drug and initiate appropriate emergency treatment with epinephrine, oxygen, IV steroids, intubation or other therapy as ertapeneem. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases. Etapenem general, unless the infant is allergic to ertapenem, breast-feeding is likely safe during maternal carbapenem therapy; observe the infant for potential effects.

Products inhibiting peristalsis are contraindicated in this clinical situation. IV or IM broad-spectrum carbapenem antibiotic stable against beta-lactamases Used to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxis Once-daily dosing may be advantageous, but no P.

Carbapenems can reduce serum concentrations of valproic acid to subtherapeutic levels when the two drugs are administered together. Patients should be told to complete the full course of treatment, even if they feel better earlier.

Ertapenem for Injection — AuroMedics Pharma LLC

Ertapenem is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.

The concentration in breast milk 24 hours after a 1 g dose ranged from less than 0. Ertapenem inesrt administered via intravenous IV or intramuscular IM routes. There are no data on the effects of ertapenem on the breast-fed infant or on milk production.

Ertapenem exhibits bactericidal activity due inhibition of cell wall synthesis mediated via binding to penicillin binding proteins PBPs. In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to antibacterial administration. Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted.

Safety and efficacy have not been established. Most patients with skin and soft tissue infections do well with 1 to 2 weeks of therapy. It is known that systemic use of antibiotics predisposes patients to packag of pseudomembranous colitis. Ertapenem is not a substrate for P-glycoprotein mediated transport. If diarrhea develops during therapy, the drug should be discontinued. Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such as srtapenem thrush, colitis, or vaginitis.

Ertapensm Concomitant use of carbapenems doripenem, ertapenem, imipenem, meropenem and valproic acid is not recommended. Therefore, these antibiotics should be taken at least 2 hours before and not less than 6 hours after the administration of sodium picosulfate; magnesium oxide; anhydrous citric acid solution.

  COMIC 13 RUE DEL PERCEBE PDF

Infants and Children 3 months to ertapneem years. No data are available regarding use in pediatric patients with renal impairment. Prior to initiating ertapenem therapy, the patient should be carefully questioned about previous penicillin hypersensitivity, cephalosporin hypersensitivity, allergic reactions to other beta-lactams e.

paackage

The diluted solution may be refrigerated for up to 24 hours 5 degrees C and used within 4 hours after removal from refrigeration. Send the page ” ” to a friend, relative, colleague or yourself.

Patients who have experienced anaphylactic reactions to penicillins or cephalosporins should not receive ertapenem. FDA-approved dosage in renal failure for adults: Sodium picosulfate; Magnesium oxide; Anhydrous citric acid: Antibiotic therapy should be administered until further debridement is not necessary, the patient has improved clinically, and fever has been absent for 48 to 72 hours.

Inhibition of vitamin K synthesis due to alterations in the intestinal flora may be a mechanism; however, concurrent infection is also a potential risk factor for elevated INR. The IM reconstituted formulation is not for IV use.

The toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis. May consider IM administration as an alternative to IV administration in the treatment of infections where IM therapy is appropriate; etrapenem, only administer via IM injection for 7 days. During clinical studies, seizures occurred in 0. Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic ergapenem therapy; a careful medical history should be taken.

PDR Search

For surgical infection prophylaxis for elective colorectal surgery. The MICs are defined for Enterobacteriaceae as susceptible at 0. Activity is maintained by the parent drug until the beta-lactam ring is hydrolyzed resulting in an inactive metabolite. Infuse IV over 30 minutes. Related Drug Information Drug Summary. Moderate The concomitant use of warfarin with many classes of antibiotics, including carbapenems, may result in an increased INR thereby potentiating the risk for bleeding.