Crossopteryx is a monotypic genus of flowering plants in the Rubiaceae family. The genus contains only one species, viz. Crossopteryx febrifuga, which is found . Crossopteryx febrifuga. Rubiaceae. (G. Don.) Benth. Crossopteryx febrifuga (Paul Latham). Crossopteryx febrifuga flower and fruit (Paul. Latham). Preparations of Crossopteryx febrifuga (Afzel.) Benth. (Rubiaceae) are widely used in Northern Nigeria in the therapeutic management of.

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Effect of the extract on piroxicam-induced gastric ulceration Piroxicam produced focal haemorrhagic gastric lesions and inflammation of the stomach mucosa in the rats. Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rats: Assessing African medicinal plants for efficacy and safety: Graph pad prism version 5.

Flora of Zimbabwe: Species information: individual images: Crossopteryx febrifuga

These were then processed routinely and the tissues were embedded in paraffin wax. Flavonoids have attracted the attention of many researchers because of their wide range of biological activities Lewis and Hanson,including antiulcer properties La Casa et al.

Preparations of the tree is used traditionally for symptomatic relief of dry cough and for treatment of septic wounds, respiratory infections, fever, dysentery and pain. Several plants containing high amounts of saponins have been shown to possess antiulcer activity in several experimental bioassays Yamahara et al, ; Yesilada and Takaish, ; Morikawa et al, probably acting as an activator of mucus membrane protective factors Saito et al.

Cyclooxygenase-2 inhibition increases gastric tone crossoptedyx delays gastric emptying in rats. The resultant mixture was filtered using Whatman filter paper No. This class of secondary compounds is able to feebrifuga the gastric mucosa against a variety of antiulcerogenic agents, particularly through scavenging properties on oxygen radicals by inhibition febrifuba nitric oxide Synthase activity Di Carlo et al.

Factors that may contribute to the protection of mucosa, such as mucus and bicarbonate secretion are dependent on gastric blood flow Guth et al. Focal infiltration of inflammatory cells into mucosa areas. Stimulation of rat gastric mucosal leukotriene C4 formation by ethanol and effect of gastric protective drugs.

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Crossoptreyx studies have shown that the methanolic stem bark extract of Crossopteryx febrifuga possesses febrivuga analgesic and anti-inflammatory properties possibly mediated via Non-selective inhibition of cyclo-oxygenase pathways.

These rats were also observed for signs of toxicity and mortality for the first critical 4h and thereafter daily for 7 days.

In the ethanol-induced ulcer assay, the control group treated orally with ethanol clearly produced the expected characteristic zone of necrotizing mucosal lesions. Table 3 Results croswopteryx Histopathology examinations.

In conclusion this study illustrated the safety of Crossopteryx febrifuga in gastrointestinal tract when used as an antiinflammatory analgesic agent that could be developed for management of painful inflammatory disorders. Piroxicam caused extensive mucosal atrophy, infiltration by eosinophils and lymphoplasma cells of the wall.

West African Plants

Histopathological studies further confirmed the extract’s mucosal protective effect in that it inhibited both piroxicam – and ethanol induced mucosal atrophy, infilteration by eosinophils and lymphoplasma cells in the wall glandular destruction, focal infiltration of inflammatory cells into mucosa areas. Acknowledgements The authors are grateful to the management of National Institute for Pharmaceutical Research and Development for provision of enabling environment and facilities used for the study.

Indian J Physiol Pharmacol. The number of deaths in each group within 24 h was recorded and the final LD 50 values were calculated as the geometric mean of the highest nonlethal dose with no deaths and the lowest lethal dose where deaths occurred. Preventive ratio PR defined as the degree of protection offered crossoptery a treatment against ulcer causing agent was calculated using the formula:. Abstract Preparations of Crossopteryx febrifuga Afzel.

Crossopteryx febrifuga

Thirty mins later, 1ml of absolute corssopteryx was administered to all the rats in groups 2—6. Ulcer index UI defined as the severity of damage caused by an ulcer inducing agent was then calculated using the formula:. The cytoprotective effect of the extract may have been due to its ability to promote secretion of bicarbonate and production of mucus. Studies by Santo et al. These were then examined by a consultant histopathologist. Ethanol caused destruction of several glandular areas and focal infiltration of inflammatory cells into the sub mucosa areas.


Considering its widespread use in traditional medicine for the management of pain and inflammatory disorders such as arthritis, the need to investigate its safety on the gastrointestinal tract cannot be over emphasized. In the stomach, prostaglandins is critical for the maintenance of gastric mucosal integrity, but the mechanism involved in the cytoprotective action of prostaglandins is still incompletely understood.

The ulcer lesions were scored according to severity Larach and Malagelada, as follows: The extract profoundly antagonized the Piroxicam- induced ulceration in rats. Oxygen free radical and lipid peroxidation in the cebrifuga of gastric mucosal lesions induced by indomethacin in rats. Statistical Analysis Graph pad prism version 5.

The authors are grateful to the management of National Institute for Pharmaceutical Research and Development for provision of enabling environment and facilities used for the study.

Group 1 rats served as febrifiga normal control received no treatment. Six hours after piroxicam administration, the rats crossoopteryx all the groups were sacrificed under diethyl ether anesthesia.

Support Center Support Center. National Center for Biotechnology InformationU. One hour after ethanol administration, the rats were sacrificed under diethyl ether anaesthesia. Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.

Effect of Crossopteryx febrifuga on ethanol-induced gastric ulceration in rats. Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. The anti-ulcer effect of the extract may have been produced via enhanced prostaglandin synthesis, inhibition of leukotriene biosynthesis and decreased acid secretion. Shows ulceration of mucosa layer of group treated with ethanol only Magnification X Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action.