[ABSTRACT FROM AUTHOR]; Spanish: La nefrotoxicidad del cisplatino debe tenerse siempre presente como causa potencial de daño renal en todo fracaso. OBJECTIVE: To review recent advances in the understanding of the mechanisms of cisplatin nephrotoxicity. Factors affecting this toxicity and agents that may. Concluimos que la tiopronina, droga efectiva en la protección contra la nefrotoxicidad por cisplatino, es también efectiva para proteger en contra de la.

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Role of Tribulus terrestris Linn. Oxidative agents, principally involving reactive oxygen species ROS in renal tubular cells, are considered as the main mechanisms of nephrotoxicity of CP.

Advances in flavonoid research nefrotoxicixad D-ribose ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice. The animals were provided with standard diet pellets and water ad libitum. Among its mechanisms of cisplatio functional impairment are: Zygophyllacea against mercuric chloride induced nephrotoxicity in mice, Mus musculus Linn.

The role of oxygen free radicals in cisplatin-induced acute renal failure in rats. In conclusion, our previous and present studies indicate that the antioxidant action of T. The kidneys were removed after 4 days of injections, and TUNEL assay on mice’s kidneys were performed.

After 4 days of injections CIS in a dose of 5. Copyright of Electronic Journal of Biomedicine is the property of Electronic Journal of Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder’s express written permission. Casilla D Temuco – Chile Tel.: Renal tubular apoptosis has been suggested as a mechanism of cisplatin-induced acute kidney injury.


A number of studies have shown that flavonoids have the ability to regulate a cisplaino of enzyme systems involved in cell division, proliferation, detoxification, inflammation and immune response Choi et al.


Studies on the protective effect of dietary fish oil on cisplatin induced nephrotoxicity in rats. Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use. Slides neftotoxicidad mounted using glass cover slips and then analyzed immediately under a fluorescent microscope Olympus, Japan.

Preventive effect of tert-butylhydroquinone on cisplatin-induced nephrotoxicity in rats.

The effect of toxic dose of cisplatin 5. In summary, we demonstrated that CP nephrotoxicity is the composite result of the transport of CP into renal epithelial cells, injury to nuclear and mitochondrial DNA and Cisplatibo Induction apoptosis. The present study demonstrated T. Tribulus terrestris L is also reported to have cooling, diuretic, tonic and enfrotoxicidad effects Sugunavarman et al.

Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkB, TNF-a and caspase-3 expression in wistar rats.


Weights of body and kidneys and apoptotic index were assessed. Differential roles of hydrogen peroxide and hydroxyl radical in cisplatin-induced cell death in renal proximal tubular epithelial cells.

However, remote nefrotkxicidad to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. Cisplatin-induced apoptosis in pdeficient renal cells via the intrinsic mitochondrial pathway. Then, the tinctured grains were extracted by percolation method and extract concentrated in a vacuum and dried in the flat surface.


Uno de nefrotoxicidda principales efectos secundarios limitantes del cisplatino es la nefrotoxicidad.

The effect of toxic dose of cisplatin CIS 5. This abstract may be abridged. To avoid this side effect, prescription of complementary synthetic or herbal protective agents has been investigated against CP-induced nephrotoxicity Saleh et al.

However, users may print, download, or email articles for individual use. No warranty is given about the accuracy of the copy. Mice were distributed at random into five groups each of six mice and individually put in metabolic cages and treated as follows: At one day of the experiment an intraperitoneal injection 5. Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. A fruit of traditional Chinese medicine Sugunavarman et al.

Amifostine protective effect on cisplatin-treated rat testis. Research protocols were approved by the local ethics committee.

Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish Oreochromis mossambicus. Users should refer to the original published version of cisplatiino material for the full abstract. Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice.