74178 DATASHEET PDF

Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by dtaasheet glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7. Find your product Go. We wish you a successful !

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74178 Datasheet

The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers. Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical datsheet proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.

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Please let us know! By proceeding on this website, you agree to the placement of these cookies. Datasheet Datasheet CST The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, Is your country not in this list? The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC. You will receive an e-mail containing a link to start the recovery procedure within minutes.

74178 Datasheet PDF

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Application References Have you published research involving the use of our products? Login Create new account. Contact us and we will help you. Have trouble resetting your password? The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.

Login No need to login to view prices! While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation Please change your password to something memorable and secure upon logging in.

The same sequence of a base pair DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC. Like most websites, we make use of cookies to track your preferences. Enter your username and we will send you a link to reset your password if an associated user is found. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9.

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Have you published research involving the use of our products? The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue.

Please select a country. TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain 7178 embryonic stem cells 5, 8. As shown in the graph, the antibody only binds to the oligo containing 5-fC.

Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, Therefore webshop 7178 that were only used to view prices have been deleted. Please create a new account with your shipping and billing details if you would like to be able to order or view your discount.

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